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Differentiate w.r.t. a
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\frac{\left(-a\right)^{-1}\left(b^{2}\right)^{-1}c^{-1}}{a^{-2}bc^{-1}}
Expand \left(\left(-a\right)b^{2}c\right)^{-1}.
\frac{\left(-a\right)^{-1}b^{-2}c^{-1}}{a^{-2}bc^{-1}}
To raise a power to another power, multiply the exponents. Multiply 2 and -1 to get -2.
\frac{b^{-2}\times \frac{1}{-a}}{a^{-2}b}
Cancel out \frac{1}{c} in both numerator and denominator.
\frac{\frac{1}{-a}}{a^{-2}b^{3}}
To divide powers of the same base, subtract the numerator's exponent from the denominator's exponent.
\frac{1}{\left(-a\right)a^{-2}b^{3}}
Express \frac{\frac{1}{-a}}{a^{-2}b^{3}} as a single fraction.
\frac{1}{-a^{-1}b^{3}}
To multiply powers of the same base, add their exponents. Add 1 and -2 to get -1.