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Differentiate w.r.t. z
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\frac{-4yw^{2}t\left(-3\right)xz^{2}\left(-t^{2}\right)}{\left(-x\right)yz^{3}w^{2}t^{3}\left(-2\right)w^{2}}
To multiply powers of the same base, add their exponents. Add 1 and 2 to get 3.
\frac{-4yw^{2}t\left(-3\right)xz^{2}\left(-t^{2}\right)}{\left(-x\right)yz^{3}w^{4}t^{3}\left(-2\right)}
To multiply powers of the same base, add their exponents. Add 2 and 2 to get 4.
\frac{-3\left(-2\right)x\left(-t^{2}\right)}{-\left(-x\right)zt^{2}w^{2}}
Cancel out 2tyw^{2}z^{2} in both numerator and denominator.
\frac{6x\left(-t^{2}\right)}{-\left(-x\right)zt^{2}w^{2}}
Multiply -3 and -2 to get 6.
\frac{6x\left(-t^{2}\right)}{xzt^{2}w^{2}}
Multiply -1 and -1 to get 1.
\frac{6\left(-t^{2}\right)}{zt^{2}w^{2}}
Cancel out x in both numerator and denominator.
\frac{-6t^{2}}{zt^{2}w^{2}}
Factor the expressions that are not already factored.
\frac{-6}{zw^{2}}
Cancel out t^{2} in both numerator and denominator.