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Differentiate w.r.t. x
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\frac{\left(-3\right)^{-4}\left(x^{-4}\right)^{-4}y^{-4}}{\left(5x^{-2}y^{3}\right)^{0}}
Expand \left(-3x^{-4}y\right)^{-4}.
\frac{\left(-3\right)^{-4}x^{16}y^{-4}}{\left(5x^{-2}y^{3}\right)^{0}}
To raise a power to another power, multiply the exponents. Multiply -4 and -4 to get 16.
\frac{\frac{1}{81}x^{16}y^{-4}}{\left(5x^{-2}y^{3}\right)^{0}}
Calculate -3 to the power of -4 and get \frac{1}{81}.
\frac{\frac{1}{81}x^{16}y^{-4}}{1}
Calculate 5x^{-2}y^{3} to the power of 0 and get 1.
\frac{1}{81}x^{16}y^{-4}
Anything divided by one gives itself.