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Differentiate w.r.t. x_2
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Evaluate
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-21x_{2}^{1-1}
The derivative of ax^{n} is nax^{n-1}.
-21x_{2}^{0}
Subtract 1 from 1.
-21
For any term t except 0, t^{0}=1.
-21x_{2}
Calculate x_{2} to the power of 1 and get x_{2}.